Unlocking Cellular Defense Mechanisms

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Prolindox, a company founded in 2020, embarked with the mission of finding ways to activate/upregulate the intrinsic biochemical mechanisms, conserved, and refined throughout evolution, that cells employ to protect against oxidative damage. This approach to protect cells against oxidative damage evolved from Dr. Weissbach’s initial discovery of the  methionine sulfoxide reductase (MSRA) system, more than 40 years ago, that repaired damage to proteins, due to oxidation of protein-bound methionine. In addition to studies on the  MSR system, Prolindox has small molecules that upregulate other important cellular protective mechanisms against oxidative damage. These cellular processes, protect against aberrant nucleic acid, protein and lipid oxidation caused by excessive reactive oxygen species (ROS). Fundamental insights into these anti-oxidative pathways, essential for life to thrive in an oxygen-laden atmosphere, make it possible to modulate these pathways to develop therapies for diseases involving oxidative damage.